M.D.

Adoptive T-cell therapy ADP-A2M4 targeting MAGE-A4 shows early activity in patients with advanced solid tumors

MD Anderson-led Phase I trial of Adaptimmune T-cell receptor therapy sees confirmed responses in multiple cancer types HOUSTON ― The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center. Among […]

Combination therapy well-tolerated and highly effective for patients with IDH1-mutated acute myeloid leukemia (AML)

Curtis Lachowiez, M.D.

Findings suggest AML treatments may be tailored to individual molecular profiles HOUSTON – A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. The results of this trial may support a novel course of action for patients with AML harboring an IDH1 […]

Residual cancer burden after neoadjuvant therapy can accurately predict breast cancer survival

W. Fraser Symmans, M.D.

Abstract: GS5-01 SAN ANTONIO ― Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden (RCB) continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes. The study’s results were presented by W. Fraser Symmans, M.D., professor of Pathology, during the 2019 San Antonio Breast Cancer Symposium. “This meta-analysis indicates that continuous RCB index is an accurate and […]

Study of tagraxofusp reports 90 percent response rate for deadly blood cancer with no prior available therapies

Naveen Pemmaraju, M.D.

HOUSTON ― An open-label, multi-cohort Phase II trial, led by investigators at The University of Texas MD Anderson Cancer Center, reports that treatment with the drug tagraxofusp resulted in high response rates in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare but highly aggressive – and often fatal bone marrow and blood disorder – for which there are no existing approved therapies. Study findings were published in this week’s online issue of the New England […]

Patrick Carter, M.D., M.B.A., F.A.A.F.P. New Board Member of American Heart Association Houston Division Board

HOUSTON (March 18, 2019) – The American Heart Association’s mission is to be a relentless force for a world of longer, healthier lives – and it starts with solid leadership. Patrick Carter, M.D., M.B.A., F.A.A.F.P., Chief of Family Medicine and Medical Director of Care Coordination and Quality Improvement at Kelsey-Seybold Clinic, began a two-year term as a board member of the American Heart Association Houston Board in November 2018. Dr. Carter joins a robust team of […]

Liquid biopsy as effective as tissue biopsy for non-small cell lung cancer according to MD Anderson study

Vassiliki Papadimitrakopoulou, M.D.

Test more accurately identifies four mutations for which FDA-approved drugs exist and offers faster turn-around time between initial testing and commencement of therapy A multi-center study led by researchers at The University of Texas MD Anderson Cancer Center revealed that a liquid biopsy test called Guardant360®, is comparable to standard tissue biopsies in detection of advanced non-small cell lung cancer (NSCLC), has a faster turn-around time, and has the potential to more specifically pinpoint biomarkers crucial for molecular therapy. […]

MD Anderson notes passing of Waun Ki Hong – innovator, mentor, colleague

Waun Ki Hong, M.D.

Former Cancer Medicine leader leaves a high-impact legacy for cancer patients, physicians HOUSTON – Waun Ki Hong, M.D., a trail-blazing physician-scientist and mentor whose clinical research innovations led to successful organ-sparing cancer treatment, advanced the field of targeted therapy and launched chemoprevention, died Wednesday at his home in California. Hong, 76, retired from The University of Texas MD Anderson Cancer Center as head of the Division of Cancer Medicine in 2014. He remained as a […]

Checkpoint inhibitor shrinks advanced squamous cell skin cancer

Michael Migden, M.D.

MD Anderson-led clinical trial shows nearly 50 percent of patients respond to cemiplimab HOUSTON – Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer, an international team led by a researcher at The University of Texas MD Anderson Cancer Center reports in the New England Journal of Medicine. “These results mark a potential paradigm shift in the treatment of patients with […]

Researchers compose guidelines for handling CAR T cell side effects

HOUSTON — Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by a team led by clinicians at The University of Texas MD Anderson Cancer Center with proposed guidelines for systematically dealing with the toxicities of these drugs. Their work, published today in Nature Reviews Clinical Oncology, confronts the two main side effects of chimeric antigen receptor T-cells, known as CAR […]

Genetically enhanced, cord-blood derived immune cells strike B-cell cancers

HOUSTON – Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia. The team’s preclinical research shows that natural killer cells derived from donated umbilical cords can be modified to seek and destroy some types of leukemia and […]