Early phase clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with RET fusion-positive cancers, high-grade (HGG) and low-grade glioma (LGG) and ovarian cancer. The results, presented today at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021, showcase the researchers’ ongoing efforts to advance clinical studies and expand potential indications of approved drugs to develop a platform for more effective treatments and to improve patient outcomes. FDA-approved […]
The University of Texas MD Anderson Cancer Center
Mutant KRAS and p53 Cooperate To Drive Pancreatic Cancer Metastasis
Preclinical research identifies CREB1 as new therapeutic target downstream of frequently mutated genes Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the deadly cancer. The findings were published today in Cancer Discoveryand presented […]
MD Anderson Researchers Recognized by AACR
Junior investigators Nicholas Navin, Ph.D., Kaysia Ludford, M.D., and Moran Amit, M.D., Ph.D., receive awards for cancer research Three researchers from The University of Texas MD Anderson Cancer Center have been honored by the American Association for Cancer Research (AACR) and will give virtual award lectures at the AACR Annual Meeting 2021: Nicholas Navin, Ph.D., associate professor, Genetics, is the recipient of the 2021 AACR Award for Outstanding Achievement in Basic Cancer Research Kaysia Ludford, M.D., assistant professor, General Oncology, is the 2020 […]
MD Anderson’s Guillermina Lozano Elected to Fellows of the AACR Academy
Guillermina (Gigi) Lozano, Ph.D., chair of Genetics at The University of Texas MD Anderson Cancer Center, has been elected to the 2021 class of Fellows of the American Association for Cancer Research (AACR) Academy in recognition of her pioneering work to describe the p53 tumor suppressor pathway, which is undermined in many cancers. The mission of the AACR Academy is to recognize and honor distinguished scientists whose contributions have propelled significant innovation and progress against cancer. This year’s class of […]
Collagen plays protective role during pancreatic cancer development
Findings suggest the protein helps slow tumor progression, pointing to new cancer therapeutic strategies Contrary to long-held beliefs, Type I collagen produced by cancer-associated fibroblasts may not promote cancer development but instead plays a protective role in controlling pancreatic cancer progression, reports a new study from researchers at The University of Texas MD Anderson Cancer Center. This new understanding supports novel therapeutic approaches that bolster collagen rather than suppress it. The study finds that collagen works in the […]