Prostate cancer bone metastases thwart immunotherapy by producing TGF-β

Prostate cancer bone metastases thwart immunotherapy by producing TGF-β

Padmanee Sharma, M.D., Ph.D.

MD Anderson researchers find abundant cytokine crowds out helper T cells crucial to treatment HOUSTON — Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell. The discoveries by a team led by Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at […]