B-cell enrichment predictive of immunotherapy response in melanoma

B-cell enrichment predictive of immunotherapy response in melanoma, sarcoma and kidney cancer

Multiple studies point to important role for B cells in promoting anti-tumor immunity HOUSTON ― The likelihood of a patient responding to immune checkpoint blockade may depend on B cells in the tumor, located within specialized immune-cell clusters known as tertiary lymphoid structures (TLS), according to researchers at The University of Texas MD Anderson Cancer Center. Studies published today in Nature conclude that enrichment of B cells, a type of immune cell known for producing antibodies, in TLS was predictive […]